Marco Vignuzzi, Ph.D.

GROUP LEADER

Current Position

Principal Investigator,
Viral Populations and Pathogenesis Group

Background

B.Sc., 1995
Microbiology and Immunology,
McGill University, Montreal, Canada

Maîtrise/D.E.A. (Masters), 1996-97
Fundamental Virology, University of
Paris – Denis Diderot, France

Ph.D., 2001
Microbiology (Virology), University of Paris VII/Pasteur Institute
(Lab of Sylvie van der Werf)

Postdoctoral Fellow, 2002-07
University of California, San Francisco (Raul Andino Lab)

H.D.R., 2010
University of Paris V - René Descartes

Publications

Ana de Casas

ADMINSTRATIVE ASSISTANT

Current Position

Adminstrative Assistant

StÉphanie Beaucourt

LAB MANAGER, TECHNICIAN

Current Position

Lab Manager, Technician

Background

Degree from the Ecole Pratique des
Hautes Etudes, La Sorbonne, 2000
Biomedical Research Specialization
Degree option virology, 1998
Diploma of technical biochemistry, 1997

Research Technician, 2006-07
Apoptosis and Immune System Group,
Department of Immunology,
Institut Pasteur (Susin lab)

Research Assistant, 2000-2006
Department of Clinical Science at South Bristol, Henry Wellcome Laboratories for
Integrative Neuroscience and Endocrinology, University of Bristol, United Kingdom (Murphy lab)

HIV technician, 2000
Virology department, teaching hospital Henri Mondor, Creteil, France
(Pawlotsky lab)

Publications

Herve Blanc

TECHNICIAN

Current Position

Technician

Background

Diploma of technical biology analysis, 1991
Molecular biology (Human genetics), 1993

Research technician, 1994-1998
Human Genetics Study on Cardiovascular Disease

Research technician and quality control, 1998-1999
Human genetics study on diabetes type 1
The Wellcome Trust Centre for Human Genetics (Oxford University), Oxford, England (Cecile Julier lab)

Research technician and quality control, 1999-2007
Human genetics study on diabetes type 1
Pasteur Institute (Cecile Julier lab)

Bioinformatics, 2007-2009
Human genetics study on immunity response to Malaria and Dengue
Pasteur Institute (Anavaj Sakhuntabai lab)

Research technician, 2009-2010
Genes spatial mapping of Saccharomyces cerevisae
Pasteur Institute (Bernard Dujon lab, Emmanuelle Fabre team)

Research technician, 2010
Sequencing of H1N1 virus
Pasteur Institute PF8 (Valerie Caro and Sylvain Brisse lab)

Research technician, 2010-Present
Deep Sequencing
Pasteur Institute (Joint work in Carla Saleh and Marco Vignuzzi lab)

Publications

NINA GNADIG, PH.D. Student

PH.D Student

Current Position

My project involves the isolation, generation and characterization of RdRp fidelity variants of Coxsackie virus B3. The mutagenic effects of several antiviral compounds are studied in tissue culture, and the relative susceptibility/resistance of fidelity variants are examined. These variants are further studied in biochemical assays. Those variants which present the most interesting alterations in mutant distribution of the populations they generate are further studied with respect to virus adaptation, evolvability and virulence/attenuation.

Background

B.S., 2007, Biology
Freie Universität Berlin, Berlin, Berlin, GERMANY

M.Sc., 2009, Microbiology
University Pierre and Marie Curie (Paris VI)/Pasteur Institute, Paris, Île-de-France, FRANCE

PH.D Student, 2009, Virology
University Diderot (Paris VII)/Pasteur Institute, Paris, Île-de-France, FRANCE

Publications

Kathryn Rozen-Gagnon, PH.D. Student

PH.D Student

Current Position

I am studying the population dynamics of arbovirus infection, using chikungunya virus as a model, both in tissue culture and in vivo. My project involves exploring how the host environment influences virus evolution and using fidelity variants of chikungunya virus, how the virus reacts to changes in selective pressures.

Background

B.S., 2010, Biology
Barnard College, Columbia University, New York, NY

Fullbright Scholar, 2011
Duke-National University of Singapore Graduate Medical School

PH.D Student, 2011, Virology
Pasteur Institute/University Paris VII International Ph.D. program

Publications

ANTONIO V. BORDERIA GINER, PH.D.

SENIOR POSTDOCTORAL FELLOW

Current Position

My main interests are RNA virus evolution and Immunology. As part of my research, I study how viral population fluctuations, involving transmission and founder events, shape virus evolution. I am also interested in understanding the response of the immune cells, mainly Dendritic Cells, against virus infections and how the virus evolves to escape the immune system.

Background

B.S., 2000, Biology
Universidad de Valencia, Burjassot, Valencia, SPAIN

Ph.D., 2007, Molecular Biology
Universidad Autonoma de Madrid, Madrid, Madrid, SPAIN

Post Doctoral Fellow, 2007, Human Immunology
Mount Sinai School of Medicine, New York, New York, USA

Post Doctoral Fellow, 2010-present
Department of Virology, Institut Pasteur, Paris, France

Publications

KENNY STAPLEFORD, PH.D.

POSTDOCTORAL FELLOW

Current Position

My research interests involve understanding the detailed molecular mechanisms required for RNA virus pathogenesis. In particular, I am interested in the dynamic host-pathogen interactions involved in these processes. My projects in the lab will focus on the role of genetic variability in arbovirus pathogenesis.

Background

B.S., 2003, Biochemistry
University of Delaware - Newark, DE USA

Ph.D., 2009, Cellular and Molecular Biology
University of Michigan - Ann Arbor, MI USA

Post-doctoral associate, 2009-2011
Yale University - New Haven, CT USA

Post Doctoral Fellow, 2011
Virology, Institut Pasteur, Paris, France

Publications

Previous Members/Visitors

Lark Coffey
Senior PostDoctoral fellow
University of Texas Medical Branch, Galveston, Texas, USA

background

Lark developed projects studying the role of population diversity on arbovirus infection and transmission dynamics in vertebrate and mosquito hosts, using chikungunya virus as a model. She currently works to discover new viruses with Eric Delwart at the Blood Systems Research Institute in San Francisco, California.

Malia J. McPherson
Pasteur Foundation Summer Student Intern
University of California, Berkeley

background

Malia joined us as part of the Pasteur Foundation's visiting student internship program available to US undergraduates (http://www.pasteurfoundation.org/internships.shtml). While here, she isolated fidelity variants of CVB3 that better replicated in the presence of high concentrations of Mg++ and Mn++.

Yashnee Beeharry
M.Sc. 2010
University of Paris VI – Pierre and Marie Curie, France

background

Yashnee joined our team as part of her Master's research work, working on the generation of fidelity variants of Chikungunya virus and the study of population diversity of Chikungunya virus in vertebrate and invertebrate cells.

Laura Levi
MD/PH.D. Program
University of Paris VI – Pierre and Marie Curie, France

background

Laura Levi obtained her Master's degree in our lab, as part of a MD/PhD program. She has since returned to medical school to complete the next part of her double degree. While in our lab, Laura contributed tremendously to the development of the Coxsackie virus projects.

Jason Kaelber
Undergraduate student
Cornell University, Ithaca, NY, USA

background

Jason joined our team in January 2009 as part of his junior year abroad from
Cornell University. He is participating in the picornavirus research projects.

Marta Sanz-Ramos Rojo, Ph.D. student
Esteban Domingo’s lab, Autonomous University of Madrid, Centro Severo Ochoa.

background

Marta joined us for a three month period in the summer of 2008, to work on developing Coxsackie virus as a study model for the role of polymerase fidelity in the generation of RNA virus genetic diversity. She has done an exquisite job in generating over 50 polymerase variants that we are now studying in the lab.